Oxidative stress involvement in chemically induced differentiation of K562 cells
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چکیده
منابع مشابه
Oxidative stress involvement in chemically induced differentiation of K562 cells.
The erythroid differentiation of K562 cells could be achieved by exposure to several pharmacologic agents, including hemin, butyric acid (BA), and anthracycline antitumor drugs such as aclarubicin (ACLA) and doxorubicin (DOX). When used at subtoxic concentrations, these drugs induce the overexpression of erythroid genes, leading to hemoglobinization of cells. Because anthracyclines are known to...
متن کاملOxidative stress in K562 cells differentiation 1 OXIDATIVE STRESS INVOLVEMENT IN CHEMICALLY-INDUCED DIFFERENTIATION OF K562 CELLS
The erythroid differentiation of K562 cells could be achieved by exposure to several pharmacological agents including hemin, butyric acid (BA) and anthracycline antitumor drugs such as aclarubicin (ACLA) and doxorubicin (DOX). When used at subtoxic concentration, these drugs induce the overexpression of erythroid genes leading to hemoglobinization of cells. Since anthracyclines are known to gen...
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The physiologically active form of vitamin D, 1,25 dihydroxyvitamin D3 [1,25(OH)2D3], was found to inhibit erythroid differentiation of human leukemic K562 cells. Differentiation was induced by 1 mumol/L arabinocytosine (Ara-C), 40 mumol/L tiazofurin, 1 mumol/L aphidicolin, or 1 mumol/L hydroxyurea, and was monitored daily by the appearance of hemoglobin in an increasing proportion of cells. Pr...
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Hydroxyurea is a differentiation-inducing agent of human erythroleukemia K562 cells. However, the cellular mechanisms by which hydroxyurea exerts its effects on tumor cells, leading to the inhibition of cell growth and the induction of differentiation markers, are largely unknown. This study examined the role of different mitogen-activated protein kinase signal transduction pathways in hydroxyu...
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Objective(s):In this study the effect of oral administration of honey on serum glucose, lipids, stress oxidative markers, and morphology of langerhans islets in noise induced hyperglycemic rats was investigated. Materials and Methods: Male Wistar rats were divided into control, hyperglycemic, honey treated control, and honey treated hyperglycemic groups. For induction of hyperglycemia, noise s...
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ژورنال
عنوان ژورنال: Free Radical Biology and Medicine
سال: 2000
ISSN: 0891-5849
DOI: 10.1016/s0891-5849(99)00195-1